fig4
![Biomarkers and therapeutic targets: microRNA roles in the pathophysiology, diagnosis and management of eosinophilic esophagitis](https://image.oaes.cc/3e84e84d-d233-48a7-8662-d80fabfc7233/2731.fig.4.png)
Figure 4. miR-21 regulates T cell polarization through direct targeting of IL-12p35. IL-12p35 is one subunit of the IL-12 cytokine that promotes differentiation of naïve T cells towards T helper type 1 cells, instead of T helper type 2. Through post-transcriptional regulation, miR-21 is able to inhibit IL-12p35, also inhibiting Th1 immunity and shifting T cell polarization and function towards T helper type 2