fig4
Figure 4. miR-21 regulates T cell polarization through direct targeting of IL-12p35. IL-12p35 is one subunit of the IL-12 cytokine that promotes differentiation of naïve T cells towards T helper type 1 cells, instead of T helper type 2. Through post-transcriptional regulation, miR-21 is able to inhibit IL-12p35, also inhibiting Th1 immunity and shifting T cell polarization and function towards T helper type 2
