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![Biomarkers and therapeutic targets: microRNA roles in the pathophysiology, diagnosis and management of eosinophilic esophagitis](https://image.oaes.cc/3e84e84d-d233-48a7-8662-d80fabfc7233/2731.fig.3.png)
Figure 3. Decreased miR-375 in EoE tissue may relieve inhibition of JAK2, promoting cytokine signaling. miRWalk 2.0 predicted that miR-375 can bind to and target JAK2 for degradation.. Based on data from esophageal biopsies, individuals with EoE have lower levels of miR-375 than their healthy counterparts. While miR-375 may normally exist to inhibit JAK2 and dampen cytokine signaling, a lack of miR-375 may remove this negative regulation allowing for more cytokine signaling to occur in EoE