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Figure 3. Decreased miR-375 in EoE tissue may relieve inhibition of JAK2, promoting cytokine signaling. miRWalk 2.0 predicted that miR-375 can bind to and target JAK2 for degradation.. Based on data from esophageal biopsies, individuals with EoE have lower levels of miR-375 than their healthy counterparts. While miR-375 may normally exist to inhibit JAK2 and dampen cytokine signaling, a lack of miR-375 may remove this negative regulation allowing for more cytokine signaling to occur in EoE