fig6
From: Aging triggers mitochondrial, endoplasmic reticulum, and metabolic stress responses in the heart
Figure 6. Aging induces mt and ER stress responses in the heart. During cardiac aging, mitochondria (mt) and the endoplasmic reticulum (ER) are two important organelles exposed to high energy demand. Initially, they adapt by upregulating the stress response, but as aging progresses, oxidative stress and damage increase, thereby predisposing the heart to dysfunction. Created using BioRender (www.app.biorender.com).
