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Figure 3. Pillars of ICI myocarditis diagnosis. The diagnosis of ICIMY can be clinical or histopathologic. A clinical diagnosis is more likely to be true with increasing pathologic findings. The clinical syndrome may include non-specific symptoms, cardiac symptoms, or comorbid IRAE symptoms. Typically, cases will have elevation in cardiac-specific troponins. Although alterations in ECG or imaging studies are not necessarily specific, the typically encountered alterations are denoted in the figure. Created with BioRender.com.