fig4
Figure 4. Ex vivo vascular function measured in thoracic aorta: EDH contribution in SMC-KO animals - IKCa/SKCa channels (A) and BKCa channels (B) to endothelium-dependent vasodilation, relative EDH contribution to vasodilation (C), EDH contribution in WT animals (D), and endothelium-dependent vasodilation in mesenteric arteries (E). Analyzed with GLM (all except for C) or 2-way ANOVA (C) with *significant effect of genotype, #significant effect of SUL-238, and $significant effect of inhibitor with P < 0.05. EDH: Endothelium-derived hyperpolarization; WT: wild-type littermates; GLM: generalized linear model; SMC-KO: DNA repair endonuclease Ercc1 knockout in vascular smooth muscle cells.
