fig3

Figure 3. Ex vivo vascular function measured in thoracic aorta: endothelium-dependent vasodilation (A), endothelium-independent vasodilation (B), relative NO contribution to endothelium-dependent vasodilation in WT and SMC-KO animals (C), NO contribution to vasodilation in SMC-KO animals (D) and logEC50 of the curves from D (E), NO contribution in WT animals (F). Analyzed with GLM (all except for C and E) or 2-way ANOVA for C and E with *significant effect of genotype, ^#significant effect of SUL-238, and ^$significant effect of pathway inhibitor with P < 0.05. NO: Nitric oxide; WT: wild-type littermates; GLM: generalized linear model; SMC-KO: DNA repair endonuclease Ercc1 knockout in vascular smooth muscle cells.