fig6

Microvascular angiotensin II type 2 receptor function is enhanced in young females and declines in a model of murine aging

Figure 6. AT2R expression in human aortic smooth muscle cells is greater in premenopausal women vs. men. The expression of angiotensin II type 2 [AT2R, (A and B)] and type 1 [AT1R, (C and D)] was quantified in primary human aortic smooth muscle cells (A and C) and endothelial cells (B and D). Samples are from adult women (average age: 37 ± 1 years) and men (average age: 34 ± 2 years) donors. Representative immunoblots and quantification are shown. N = 3-8 samples per group. Differences were assessed via the student’s t-test. Data are means ± SEM for protein expression normalized to GAPDH, *P < 0.05.

The Journal of Cardiovascular Aging

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