fig4

Figure 4. Induction of senescence in cardiomyocytes and the effectiveness of senolysis under these conditions. Stressors in the heart, including diabetes, doxorubicin (Dox), myocardial infarction or ischemia/reperfusion (IR), angiotensin II (Ang II), aging, and thoracic irradiation, induce senescence in cardiomyocytes. Senolytic drugs, including Navitoclax (N), Dasatinib (D), and Quercetin (Q), or induction of senolysis, via p16 deletion or INK-ATTAC plus AP20187, reduce the number of senescent cells, including cardiomyocytes, in the heart, thereby attenuating cardiac hypertrophy, fibrosis, and dysfunction. Specific stressors and their resultant consequences are indicated with the same color.