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Figure 2. The role of senescent cells in the heart. Senescent cells in the heart have both salutary and detrimental effects on the heart. The detrimental effects of senescent cardiomyocytes include cardiac hypertrophy, cardiac fibrosis, cardiac dysfunction, and larger myocardial infarct size. On the other hand, senescent cardiomyocytes may promote myocardial regeneration. Senescent cardiac fibroblasts may have inhibitory effects on age-related or pressure overload-induced cardiac fibrosis and dysfunction. The senescent cells (cardiomyocytes and fibroblasts together) may attenuate post-myocardial infarction (MI) cardiac fibrosis and dysfunction. The figure was generated with BioRender.com.