fig3
Figure 3. Mechanisms mediating enhanced exercise capacity in RGS14 KO and its uniquely powerful BAT. Multiple mechanisms mediated the enhanced exercise capacity in RGS14 KO mice. The most important mechanism is BAT, which mediates SIRT3, MnSOD, MEK/ERK, and VEGF pathways. These mechanisms regulate exercise capacity by improving mitochondrial function, providing protection against oxidative stress, and improving blood flow/angiogenesis. Reprinted from Ref.[72].
