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![Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes](https://image.oaes.cc/380584af-dfa5-4e15-bfec-164565bb6e4f/jca4046.fig.1.jpg)
Figure 1. A model of the protective role of Nobiletin via RORα activation. Nobiletin activates RORα, which activates autophagy/mitophagy, leading to cell protection. It should be noted that Nobiletin may induce cell survival independently of RORα, whereas RORα ’s stimulatory effect of upon may be secondary to unknown mechanisms.