fig3
![Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia](https://image.oaes.cc/ee1aec41-cfe5-4249-885e-6af5c275a2c8/jca4042.fig.3.jpg)
Figure 3. Normalization of diastolic SR Ca2+ release events due to genome editing. (A) Representative confocal line scan images showing sarcoplasmic reticulum (SR) Ca2+ sparks in ventricular myocytes isolated from R176Q/+ mice treated with control (Con) AAV9 or gRNA-SaCas9, or WT littermate mice. (B) Quantification of Ca2+ spark frequency (CaSpF), (C) SR Ca2+ leak measured using the caffeine dump protocol, and (D) ratio of Ca2+ spark frequency and SR Ca2+ load. Numbers of cells and mice are indicated. P-values are based on the nested one-way ANOVA test.