fig1

Figure 1. Representation of the risk factors that contribute to the expansion of CH mutant clones. The identified risk factors encompass a range of conditions and exposures, including aging, chemotherapy and radiation treatments, inflammatory processes, germline variants, and lifestyle factors such as smoking, body mass index, diet, and diabetes. The presence of these CH clones has been associated with substantial health risks, including the development of multiple age-associated diseases, including cardiovascular disease and hematological malignancies, and with increased all-cause mortality. The graphical representation of these risk factors has been generated using BioRender.com.