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![GDF11 and aging biology - controversies resolved and pending](https://image.oaes.cc/f09759fe-fe0c-44c9-bb37-42d9ffe99113/jca3023.fig.3.jpg)
Figure 3. Different potential states of GDF11. (i) Latent, with green and purple dimer and brown prodomains; (ii) Triggered as realized through acid activation; (iii) Tolloid processed; (iv) free ligand; and (v) antagonist bound with red and pink antagonists. + denotes active signaling states. Arrows indicate the possibility that some specific forms may change with age.