fig3

Figure 3. Heart failure with reduced ejection fraction induced by mTAC. (A) Representative M-mode echocardiography tracings from the left ventricle of sham (upper panels) and mTAC mice (bottom panels) at baseline and 2, 4, 6, and 8 weeks after surgery. (B) Average ejection fraction (EF) at the different time points in sham (black plots, n = 6) and mTAC (red plots, n = 8) mice. (C) Individual EF changes in mTAC mice at different time points. (D-G) Average of (D) fractional shortening (FS), (E) end-diastolic diameter (EDD), (F) end-systolic diameter (ESD), (G) left ventricular posterior wall at diastole (LVPW;d), and (H) LVPW in systole (LVPW;s), at the different timepoints in sham and mTAC mice. Data shown mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001, using 2-way ANOVA with Bonferroni’s multiple-comparision correction.