fig1

Figure 1. Overview of minimally invasive transverse aortic constriction (mTAC) model. (A) A schematic illustration of the incision exposing the aortic arch and ligation site. (B) Flow chart of the mTAC surgical model with time points for echocardiography (echo). (C) Procedure-derived mortality during mTAC surgery in sham (n = 6) and mTAC mice (n = 11). (D) Survival Kaplan-Meier curve for sham (black line, n = 6) and mTAC (red line, n = 10) mice during the 8-week postoperative (post-op) period. The student’s t-test was used to compare procedure-derived mortality and the Mantel-Cox test was used for survival Kaplan-Meier curve comparison.