fig4
![The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure](https://image.oaes.cc/255e1f7c-1f2f-42d0-a855-6f3e3f566de8/5367.fig.4.jpg)
Figure 4. Myocardial structural remodeling impairs mitochondrial energetic supply and demand. ROS: Reactive oxygen species; HIF-1: hypoxia-inducible factor 1; OXPHOS: oxidative phosphorylation; TCA: tricarboxylic acid; PGC-1α: peroxisome proliferator-activated receptor γ co-activators 1α; PKB: protein kinase B. See Section “CARDIAC REMODELING ALTERS MITOCHONDRIAL BIOENERGETICS” for further details.