fig3

Figure 3. Mitochondrial dysfunction and downstream consequences trigger and exacerbate myocardial structural remodeling. ECM: Extracellular matrix; ROS: reactive oxygen species; TGF: transforming growth factor beta; PPAR: peroxisome proliferator-activated receptor; CPT1b: carnitine palmitoyltransferase 1b; TCA: tricarboxylic acid; DAG: diacylglycerol; GSH: glutathione; mPTP: mitochondrial permeability transition pore; UCP: uncoupling protein; MOMP: mitochondrial outer membrane permeabilization; PGC-1: peroxisome proliferator-activated receptor γ co-activators 1; GlcNAc: O-GlcNAcylation. See Section “MITOCHONDRIAL DYSFUNCTION DRIVES CARDIAC REMODELING” for further details.