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![The dynamic interplay between cardiac mitochondrial health and myocardial structural remodeling in metabolic heart disease, aging, and heart failure](https://image.oaes.cc/255e1f7c-1f2f-42d0-a855-6f3e3f566de8/5367.fig.1.jpg)
Figure 1. Altered systemic metabolism, aging, protein hyperacetylation, and calcium overload all mechanistically contribute to cardiac mitochondrial dysfunction. ROS: Reactive oxygen species; mtDNA: mitochondrial DNA. See Sections “Systemic metabolic alterations” and “Cardiac aging” for further details.