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![The role of paracrine crosstalk between myeloid and endothelial cells in myocardial angiogenesis and infarcted heart repair](https://image.oaes.cc/737e087f-cfbf-450d-8aea-248ff8f7f5eb/5228.fig.1.jpg)
Figure 1. A schematic summary for the paracrine crosstalk between myeloid and endothelial cells (ECs) for vascular repair of the injured heart. In response to myocardial infarction (MI), CCR2+ myeloid cells infiltrate the heart and secrete METRNL which binds to KIT tyrosine receptor expressed on a subset of cardiac ECs. The KIT-METRNL signaling cascade induces the proliferation and migration of KIT+ ECs, contributing to tissue repair.