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![Small molecules that enhance mitophagy to delay aging and neurodegeneration](https://image.oaes.cc/bfd14cb9-925b-41a1-a3cc-d0b2d444eb08/5151.fig.1.jpg)
Figure 1. Structures, predicted chemical properties, and mitophagy activating pathway of Spermidine and VL-004, described by Srivastava et al. “Log P” is the water octanol partitioning coefficient[3]; “MR” is molar refractivity; “Henry’s law” is solubility constant; “Heat of form” (formation) is enthalpy; “tPSA” is topological polar surface area. Neither compound has any exception to Lipinski’s rule, suggesting that they both have pharmaceutical properties of orally active drugs.