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![Mutant SRF and YAP1 remodel the chromatin to entice cardiac myocyte nuclear division](https://image.oaes.cc/5cfc54af-bc63-42e9-b82f-c462d9ef0749/5021.fig.1.jpg)
Figure 1. Replication of mature cardiac myocyte nuclei upon delivery of synthetic modified mRNAs expressing STEMIN and YAP5SA. (A) Transfection of mature cardiac myocytes with constructs expressing modified STEMIN [SRF153(A3) and YAP5SA]. (B) Disassembly of cardiac myocyte sarcomere structure, chromatin remodeling, and reversion to a immature state. (C) Nuclear division generating diploid and tetraploid myocytes.