fig3
![STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts](https://image.oaes.cc/544e1c3f-4623-4377-9f8d-8397fe907fb8/4972.fig.3.jpg)
Figure 3. Injected STEMIN and YAP5SA mmRNA induced cell replication and DNA replisome factors. (A) In a second injected heart, anti-phospho-histone H3 stain of a serial section was observed along two needle tracts marked by white arrows. Robust EdU stain overlap anti-pHH3 stains exactly in the same orientation and location. A key component of the DNA replisome was stained by anti-CLASPIN overlapped anti-pHH3 and Edu stains. Anti-NANOG stained NANOG was observed, but peaked levels were probably about 12 h earlier[15]. (B) In a third injected heart, anti-ORC2 (Origin recognition complex subunit 2) and anti-MCM2 showed the stained markers of the pre-initiation phase in early G1 stage induced in the injected hearts. Anti-ATR stained Ataxia telangiectasia and Rad3-related, an essential kinase that is active in S phase which overlapped other DNA replisome factors. Thus, STEMIN and YAP5SA mmRNA treatment fostered cell cycle entry by promoting DNA replication in the G1 phase.