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![The WNT/β-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes](https://image.oaes.cc/d1186b0b-486b-41e3-943b-ab007481488f/4577.fig.8.jpg)
Figure 8. Effects of suppression or activation of the β-catenin on myocardial fibrosis in 4-week-old mice. (A) Picrosirius red-stained thin myocardial sections in 4 weeks old wild type, Myh6-Mcm, β-catenin LoF and GoF hearts showing no change in myocardial fibrosis. (B) Quantitation of myocardial fibrosis presented as % collagen volume fraction (CVF) in the experimental groups (n = 5). (C) RT-PCR data showing transcript levels of genes involved in myocardial fibrosis in the β-catenin LoF and GoF hearts along with the control hearts (n = 5). Myh6-Mcm: Myosin heavy chain 6-MerCreMer; RT-PCR: reverse transcription-polymerase chain reaction; GoF: gain-of-function; LoF: loss-of-function.