fig1

Figure 1. WJMSC expansion and EV manufacturing in the quantum bioreactor. (A) Recorded values of the daily lactate production during WJMSC expansion. (B) The daily prediction of cell numbers within the bioreactor. (C) The average number of EVs isolated at each collection point. (D) The average total number of EVs collected in a single bioreactor run. (E) The average mode size of the EV harvest at each collection time point. (F) The average mode size of the EVs isolated from a single bioreactor run. *P < 0.05, ***P < 0.001. WJMSC: Wharton’s Jelly-derived mesenchymal stem cell; EVs: extracellular vesicles; PLT: human platelet lysate; FBS: fetal bovine serum.