fig3

Figure 3. Effects of suppression of the cWNT pathway on myocardial fibrosis. (A) Low magnification images depicting picrosirius red stained thin myocardial sections in the wild type and Myh6-Cre:Dsp^W/F mice, either untreated, and treated with a placebo or WNT974. (B) High magnification images depicting thin myocardial section stained with picrosirius red in the experimental groups. (C) Bar graphs showing collagen volume fraction (CVF), as determined by the morphometric analysis of at least 6 high magnification field per section, 6 sections per mice, and 7 to 11 mice per group. P_G: P value for the effect of the genotype; P_Tr: P value for the effect of treatment; P_i: P value for treatment-by-genotype interaction.