fig6

Figure 6. IRM are regulated by the ribosome pathway. (A) Correlation heatmap analyzed the association between modules and differentially expressed IRM genes; (B and C) KEGG Analysis of cyan (B) and brown (C) modules; (D) Correlation heatmap analyzed the association between differentially expressed genes on ribosome pathways and IRM genes; (E) Molecular network of differentially expressed genes on ribosome pathway (blue) and IRM genes (red); (F) The bubble chart shows the expression level and different significance of the genes lying in the center of the molecular network diagram in the native sEVs and the IFNγ-sEVs. IRM: Interferon-responsive microglia; KEGG: Kyoto Encyclopedia of Genes and Genomes; IFNγ: interferon-gamma; sEVs: small extracellular vesicles.