fig2

Figure 2. IFNγ-sEVs inhibit the inflammation signal pathway in the retina after ONC. (A) Volcano plot of genes that are highly and lowly expressed in the retina of the IFNγ-sEVs-treated group compared to the native sEVs-treated group (n = 3 retinal samples from ONC mice, with adjusted P-values ≤ 0.05); (B) GO analysis of DEGs in the IFNγ-sEVs group compared with the native sEVs group; (C) KEGG analysis of DEGs in the IFNγ-sEVs group compared with the native sEVs group; (D-H) Significantly downregulated gene sets associated with inflammation signal pathway in the IFNγ-sEVs-treated group compared with those native sEVs-treated group determined by GSEA. ONC: Optic nerve crush; sEVs: small extracellular vesicles; DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; GSEA: Gene Set Enrichment Analysis; GO: Gene Ontology; IFNγ: interferon-gamma.