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Figure 2. The three types of adipocytes. White adipocytes are characterized by a large lipid droplet and low mitochondria density and UCP1 expression. These adipocytes are responsible for energy storage, being capable of incorporating FA. They are mainly located under the skin and around the visceral organs. Due to a variety of stimuli, white adipocytes can transdifferentiate into beige adipocytes. Beige adipocytes have medium size lipid droplets and mitochondria density. Brown adipocytes are very metabolically active, being characterized by a high β-oxidation activity, sustained by a high mitochondria density. Due to this metabolic signature, they contain several small lipid droplets and very high UCP1 levels. These adipocytes are responsible for generating heat. Brown adipocytes are located above the clavicles, along the spine, in the armpits, and cervical area. Created with Biorender.com. UCP1: Uncoupling protein 1; FA: fatty acids.