fig1

Figure 1. Non-Hodgkin lymphoma (NHL) refers to cancers that develop through B, T, and natural killer (NK) cells in the lymphatic system^[35]. (A) Lymphatic System: Tissues and organs susceptible to NHL include the lymph nodes, tonsils, thymus, spleen, bone marrow, and intestines via the mucosa-associated lymphoid tissue (MALT) and Peyers’ patches^[36]. (B) Lymph Node: Blood and lymph interface for lymphocyte recirculation^[37]. (C) Germinal Center: B cells account for about 85% of NHL cases in the United States, with T cells less than 15% and NK cells less than 1%^[38]. (D) 40x H&E Stain of DLBCL in Lymph Node: Diffuse large B-cell lymphoma (DLBCL), the most common form of NHL, is identified in a hematoxylin and eosin stain by the neoplastic B cells with large vesicular nuclei (green arrows) and mitotic bodies (blue arrows) among the diffuse proliferation of lymphocytes^[39] (the images in the figure are not drawn to exact scale).