fig3

Figure 3. The in vivo distribution of free PTX and PTX encapsulated in CDEVs. (A) Schematic representation of in vivo distribution experiment in LLC tumor-bearing mice; (B) IVIS imaging of CDEVs-PTX and PTX; (C) The distribution of CDEVs-PTX and PTX in organs and tumors at 24 and 48 h post-administration; (D)In vivo distribution of CDEVs-PTX (A) and PTX (B) at 24 and 48 hours post-administration; (E and F) Tumor distribution and fluorescence signal quantification results of CDEVs-PTX and PTX. Data are represented as mean ± SD. CDEVs: Celery-derived extracellular vesicles; PTX: paclitaxel; LLC: Lewis lung carcinoma. (n = 3; ^*P < 0.05).