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Figure 2. EVs as mediators of the communication between PCCs and TME in PC. The content of EVs derived from PC and from TME cells is capable of modulating PC progression. Pancreatic cancer cells (PCCs), pancreatic stellate cells (PSCs), tumor-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), NK cells, endothelial cells, and dendritic cells (DCs). Figure created with Biorender.