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Figure 3. Sustained type 1 interferon signaling promotes TNBC cancer progression. (A) 4T1 primary tumor growth following im injection overtime in WT and SA knock-in mice (n = 8); (B) Representative images of excised primary 4T1 tumors; (C) Kaplan-Meier curve comparing cancer-related survival of WT and SA knock-in mice following 4T1 primary tumor resection (n = 8); (D) Representative H&E staining of lungs from WT and Ch25h^-/- mice exhibiting respiratory distress after EO771 primary tumor resection. Quantitative data are represented as mean ± SEM; P values: * P < 0.05; ** P < 0.01; *** P < 0.001 from Anova test. SA: Ifnar1S526A; WT: wild-type.