fig7

Figure 7. Gene target prediction and Gene Ontology (GO) enrichment analysis for miRNA uniquely present in sEV. (A) gene targets for 25 miRNA uniquely present in sEV were identified using miRNET, targetScan, and miRWalk miRNA target prediction tools and identified 95 shared/overlapping genes; (B) pathway analysis identified 95 genes that regulate mostly immune and inflammatory function (highlighted as exploded portions of the pie chart). This indicates 25 miRNA unique to sEV relates to immune function.