Extracellular Vesicles and Circulating Nucleic Acids

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From: Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin

Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin

Figure 2. Protein network analysis of proteins shared by mTau and mPS1 EVs. (A) Shared biological pathways of mTau and mPS1 EV proteomes. Shared proteins of mTau and mTPS1 EVs^[24,25] were assessed for functional biological pathways by GO analysis using FDR significance levels of < 0.05. In fact, highly significant FDRs are indicated of 10^-24 to 10^-28; (B) Hub proteins of interaction networks. Protein components of hubs of protein interaction networks of groups 1-3 are listed. Functions of these proteins are provided in Supplementary Table 2; (C) STRING-db protein interaction networks of proteins shared by mTau and mPS1 EVs. Interaction utilized scores set to high confidence (0.7 on a scale of 0-1) that predicted interactions exist among the proteins illustrated. EVs: extracellular vesicles.