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Figure 1. Tissue distribution of milk sEVs in mice. (A) Distribution of bovine milk sEVs loaded with fluorophore (ATTO)-labeled miR-375 in Balb/c mice. Modified from Manca et al. with permission from the original publisher, Nature Springer^[13]. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/; (B) Accumulation of enhanced green fluorescence protein (eGFP)-positive milk sEVs in peripheral tissues and the small intestinal mucosa in wild-type (WT) pups fostered to exosome and cargo tracking (ECT) dams and nursed for 17 days. ECT mice secrete sEVs labeled with an eGFP fusion protein in milk. WT pups fostered to WT dams served as controls. From Zhou et al. with permission from the original publisher, Frontiers Media SA^[22]. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.