fig4

Figure 4. GPI-APs can be sorted to apical cell surface through two distinct mechanisms. The left side depicts the lipid-based sorting mechanism in the Golgi, where remodeling of GPI-APs allows for clustering into lipid-ordered domains that leads to apical sorting. The right side depicts the oligomerization-based sorting mechanism in the Golgi, where oligomerization of GPI-APs through ectodomain interactions allows for clustering and sorting to the apical cell surface.