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![Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept](https://image.oaes.cc/eab2ffc8-1f80-4813-a899-42bd9184ef92/5581.fig.3.jpg)
Figure 3. p181-Tau and Aβ42 in NDEVs in three cohorts. The levels of p181-Tau, total Tau, and Aβ42 were measured in three cohorts of early-stage AD patients and control donors. (A, B) NDEVs-associated p181-Tau and Aβ42 were measured by a Milliplex assay in the BioIVT cohort (N = 10 per group, P = 0.007 and P < 0.0001, respectively). (C, D) Different aliquots of the same 20 plasma samples from the BioIVT cohort were analyzed again at a later date to assess the correlation between the two measurements (R2 = 0.93, P < 0.01 and R2 = 0.55,