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![Hijacking intercellular trafficking for the spread of protein aggregates in neurodegenerative diseases: a focus on tunneling nanotubes (TNTs)](https://image.oaes.cc/f2cf4dc7-d044-42f5-a55c-969b69f506c2/5498.fig.2.jpg)
Figure 2. Functional nature of TNTs is defined by their ability to facilitate material transfer between connected cells. A: Cells connected by TNTs can allow for exchange of various intracellular materials, such as ions, cytosolic and plasma membrane components, nucleic acids such as messenger and/or regulatory RNAs, organelles such as lysosomes and mitochondria, and cytotoxic protein aggregates.