fig6
Figure 6. Representative PET/MRI images of 64Cu-labeled EVs in NHP. Macrophage derived EVs were labeled with 64Cu and injected into rhesus macaque monkey (0.3 mCi/1012 particle mL-1, N = 4) via three administration routes; (A) IP, (B) IV, and (C) IT. Animals were imaged by PET/MRI over 24 h-time period after the injection. Sagittal and coronal representative images of animals suggest that 64Cu-EVs accumulate in the brain of IT injected animals at greater extent than those with IP, and IV injections. Reprinted with permission from[86].
