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Figure 6. Clinical applications of cfDNA analysis in cancer. Analysis of cfDNA has been used to develop early cancer detection tools and ctDNA mutation analysis can guide therapy choice. After treatment, minimal residual disease (MRD) can be monitored by cfDNA analysis, and in case of resistance, cfDNA-based tests allow detection of relapse and tumor metastases. CfDNA analysis has the potential to screen cancers in the asymptomatic population.