fig3

Figure 3. (A) The procedure to produce hybrid nanoparticles by membrane fusion. Liposomes with targeting molecules on the surface can be delivered into EVs through membrane fusion^[79]. Copyright 2018 WILEY-VCH. (B) The procedure to produce hybrid nanoparticles by membrane coating^[80]. Copyright 2020 Ivyspring International Publisher. (C) The fusion of the targeting peptide with LAMP-2B^[66]. Copyright 2021 Ivyspring International Publisher. (D) The fusion of the delivery molecule with CD63^[81]. Copyright 2018 Springer Nature. (E) Targeted modification of EVs based on chemical covalent reactions^[82]. Copyright 2021 Elsevier. (F) Targeted modification of EVs based on chemical non-covalent reactions^[82]. Copyright 2021 Elsevier. LAMP-2B: Lysosome-associated membrane glycoprotein 2B.