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Figure 3. Glioblastoma multiforme (GBM) is one of the most aggressive tumors of the adult brain. Cells that make up the GBM tumor, release extracellular vesicles (EVs), which mediate the transfer of vital cues between tumor cells and the surrounding microenvironment. GBM tumor mass is highly heterogenous comprising differentiated tumor cells and glioma stem cells (GSCs). GSC derived EVs are particularly important players in sustaining glioma growth and invasion. Depending on their cell of origin, GBM EVs deliver unique cargo such as proteins, nucleic acids and lipids to recipient cells, to possibly alter their gene expression profile and phenotypes, and in the process favor malignant transformation. Some critical functions attributed to GBM EVs include (1) supporting tumor growth and survival; (2) promoting angiogenesis by regulating gene expression in endothelial cells; (3) mediating immune evasive phenotype changes in tumor associated immune cells: T cells, macrophages and microglia; (4) inducing resistance to chemotherapy drugs/ radiation therapy. GBM: Glioblastoma multiforme; EVs: extracellular vesicles.