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Figure 1. Recent advances in portable or wearable devices for automatic and rapid blood sample collection for biomarker detection. (A) Microneedle-based skin patch for rapid and wearable blood test[2]; (B) Quantitative detection of blood cardiac troponin I and creatine kinase-MB level using surface-enhanced Raman scattering (SERS) with nanoparticle-based immunoassay[3].