fig1

Figure 1. The effect of factors from the peripheral circulation during cardiac surgery on the disruption of the blood-brain barrier and the escalation of inflammatory processes in the brain tissue, which lead to impairment of cognitive functions. BBB: Blood-brain barrier; CABG: coronary artery bypass surgery; COX: cyclooxygenase; CPB: cardiopulmonary bypass; LOX: lipoxygenase; NOX: NADPH oxidases.