fig3

Figure 3. There were no significant changes in myocardial infarct size or border zone interstitial fibrosis after either IM or IV human bone mesenchymal stem cell-derived extracellular vesicle (HBMSC-EV) injection. (A) The infarct percentages of all four groups were not found to be significantly different (P = 0.05620). Representative images of the infarct size in each of the four groups are shown. Scale bar = 1 mm. (B) Anterior border zone interstitial fibrosis was not found to be significantly different (P = 0.6333). Scale bar = 100 µm; IM-C, IM control injection group; IM-EV, IM extracellular vesicle injection group; IV-C, IV control injection group; IV-EV, IV extracellular vesicle injection group. The Shapiro-Wilk test was used to determine that the data were parametric. Then, the one-way ANOVA test was performed.