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From: Lack of cardiac benefit after intramyocardial or intravenous injection of mesenchymal stem cell-derived extracellular vesicles supports the need for optimized cardiac delivery

Lack of cardiac benefit after intramyocardial or intravenous injection of mesenchymal stem cell-derived extracellular vesicles supports the need for optimized cardiac delivery

Figure 1. Wild-type mice underwent left anterior descending coronary artery (LAD) ligation to induce myocardial infarction, and then were split into a tail vein or intramyocardial injection group to receive either human bone mesenchymal stem cell-derived extracellular vesicles (HBMSC-EV) or a negative saline control. The mice were then allowed to recover postoperatively, and underwent postoperative echocardiogram to evaluate cardiac function. The mice were euthanized on postoperative day 28 for organ harvest. This image was created using BioRender.com and used with permission.

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