fig4

Figure 4. K_ATP channel opener diazoxide was associated with improved left ventricular ejection fraction at 30 min after reperfusion in a porcine model of 30 min of regional ischemia followed by 2 h of global ischemia, simulating clinical cardiopulmonary bypass in the acutely injured heart prior to cardiac surgery. Using a translational porcine model of regional ischemia (30 min) followed by 2 h of global ischemia, animals were randomized to one of two groups: cardioplegia alone (red, n = 6) or cardioplegia plus diazoxide (blue, n = 6). Each dot represents an individual animal (n = 6 in each group). The lower and upper borders of each box represent the lower and upper quartile, respectively. The middle line represents the median, and the cross represents the mean. Left ventricular ejection fraction was measured at baseline, before regional and global ischemia, and throughout 1 h of reperfusion by transesophageal echocardiography. Statistical comparisons using Student’s t test. (A) Left ventricular ejection fraction represented as a percentage. (B) Left ventricular ejection fraction represented as percent change from baseline. (C) LVEF represented over time^[136]. This figure was previously published under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution with appropriate citation and without modification^[136]. K_ATP: Adenosine triphosphate - sensitive potassium; LVEF: left ventricular ejection fraction; RP 30: reperfusion for 30 min; RP 60: reperfusion for 60 min.