fig2
Figure 2. Summary of the benefits with use of KATP channel opener diazoxide in a translational swine model of hypothermic cardioplegic arrest and prolonged global ischemia similar to a prolonged global ischemia model for clinical cardiac surgery. Swine undergo cardiopulmonary bypass and prolonged global ischemia of the heart via placement of aortic cross clamp (120 min) with one dose of cardioplegia, similar to clinical cardiopulmonary bypass. Animals are randomized to one of two groups: cardioplegia alone or cardioplegia plus diazoxide. Animals who underwent cardioplegia plus diazoxide in this model had preserved systolic and diastolic function, suggesting that adding diazoxide to cardioplegia may result in improved outcomes[135]. This model simulates the clinical situation of a patient presenting to the operating room for a prolonged global ischemic period for cardiac surgery protected with one dose of cardioplegia[135]. This figure is used with permission from Elsevier (obtained September 4, 2023, license number 5621921258491)[135]. CPB: Cardiopulmonary bypass.
