fig1

Figure 1. Post-transcriptional regulation of RhoA in smooth muscle cells. RhoA activity is dependent on GTP and is inactive when bound to GDP. A number of protein families regulate this activation cycle, such as RhoGEFs, RhoGAPs and RhoGDIs. RhoA can also be post-transcriptionally regulated by the microRNAs miR-133a and miR-141, and post-translationally by statins. GTP: Guanosine triphosphate; GDP: guanosine diphosphate; GEF: guanine exchange factor; GAP: GTPase-activating protein; GDI: guanine dissociation inhibitor; P: phosphate.